Starring: Salli Saffioti, Audu Paden, Kate Higgins, Debi Derryberry

The series follows the main "ghoulfriends" (girlfriends) of the franchise such as Frankie Stein, Clawdeen Wolf, Draculaura, Lagoona Blue, Cleo de Nile, Ghoulia Yelps, and Abbey Bominable; and how they manage in the "Monster High" high school. Other characters appear throughout the series, such as the antagonist Toralei Stripe (a were-cat).